Endocrine Abstracts

Although the role of radioiodine (RaI) in recurrent or metastatic thyroid cancer is beyond dispute, the efficacy of this therapy is hampered by the decreased expression of the sodium iodide symporter (NIS) in DTC during the process of dedifferentiation. At present, there are no effective therapies available for RaI non-avid DTC. Conventional chemotherapy is hardly effective in DTC, and no longer recommended in international guidelines. In DTC, many genetic alterations have bee...

Growth hormone deficiency (GHD) can occur after treatment for acromegaly. It is unclear whether treatment with recombinant human growth hormone (rhGH) in these patients is beneficial. Patients were randomized to either 1 year of rhGH replacement (n=10) or placebo followed by rhGH replacement for 1 year (delayed rhGH treatment, n=6). Sixteen patients (8 men, mean age 56 years) with GHD after treatment for acromegaly were studied. Study parameters were assessed at ...

Introduction: Selenium (Se) is a trace element that plays key roles in thyroid pathology. In patients with Hashimoto thyroiditis (HT), Se supplementation might reduce antibody levels and may provide additional beneficial effects, such as on cognition.Aim: To evaluate cognitive function (cognitive decline) in patients on long-term levothyroxine replacement for primary hypothyroidism with and without selenium supplementation.Design: ...

Objective: To identify factors influencing the development of osteoarthritis during long-term control of acromegaly, focusing on disease specific parameters, growth hormone (GH) and insulin-like growth factor I (IGF-I) concentrations and duration of disease, adjusted for the well-known determinants of primary osteoarthritis.Design: Follow-up study.Methods: We studied 67 patients, with adequate biochemical control of acromegaly for ...

Introduction: In the last decade, it has become clear that not only overt but also subclinical hypo- and hyperthyroidism are associated with several adverse clinical outcomes, including atrial fibrillation, coronary heart disease, stroke and mortality. More recently, various studies have suggested that even small differences in thyroid function within the reference range are associated with clinical consequences. Genetic factors are responsible for up to 58-71% of the variatio...

Background: Tumor-associated macrophages (TAMs) with dysregulated inflammatory phenotypes play a key role in carcinogenesis. In thyroid carcinoma (TC), excessive release of proinflammatory cytokines decreases the expression of sodium-iodine transporter and inflammation potentiates tumor progression.Aim: To assess the impact of TC cells on the functional reprograming of TC-induced macrophages at the level of transcriptome and metabolic pathways, and asses...

Objective: To evaluate the impact of the genomic deletion of exon 3 in the growth hormone receptor (d3GHR) on co-morbidities of acromegaly in a well-characterized cohort of patients with long-term remission of acromegaly.Design: Cross sectional study.Methods: The presence of the d3GHR polymorphism was assessed in 86 acromegalic patients and related to clinical outcome, i.e. anthropometric parameters, osteoarthritis, and the metabol...